Physiochemical Characterization and in vitro Evaluation of Formulated Herbal Bioactive Loaded Transdermal Patches

Pharmacognosy Research,2023,15,1,64-70.DOI:10.5530/097484900244Published:December 2022Type:Original ArticleAuthors:Poojashree Verma, Neelesh Maheshwari, and Deepika Bairagee Author(s) affiliations:Poojashree Verma1, Maheshwari2, Bairagee1,* 1Faculty of Pharmacy, PAHER University, Udaipur, Rajasthan, INDIA. 2School Sangam Bhilwara, Abstract:Aim: The present research aimed to formulate a transdermal patch incorporating herbal bioactive Vitex negundo extract. polymers that were used for selected sustained release the drug are HPMC, PVP K30 polyethylene glycol as plasticizer. Materials Methods: Transdermal patches prepared using with two (HPMC K30) different polymers. films evaluated their physico-chemical characteristics such physical appearance, weight uniformity, thickness, folding endurance, moisture content, percent loss permeation studies. skin irritation study done on rat showed formulation does not produce it successful from fabricated patch. Results: in vitro F1, F2, F3, F4, F5 F6 has shown about 89.15%, 87.12%, 82.34%, 92.45%, 86.78% 76.21% at 8hr. order was found be F4>F1>F2>F3>F6>F5. Conclusion: It could concluded study, containing F4 batch highest other desirable properties can developed. Keywords:Differential Scanning Calorimetry (DSC), Fourier-Transform Infrared Spectroscopy (FTIR)., Physico-chemical properties, Stability, Transdermal, UV/Vis SpectroscopyView:PDF (572.04 KB)